Description

3-Fluoro-2-Trifluoromethylpyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, imparts significant electronic and steric properties essential for developing novel compounds. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating new active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and other functional materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a difluoromethylpyridine moiety.

Basic Information

Product Name	3-Fluoro-2-Trifluoromethylpyridine
CAS No.	886510-21-0
Molecular Formula	C6H3F4N
Molecular Weight	165.09 g/mol
Synonyms	2-(Trifluoromethyl)-3-fluoropyridine; 3-Fluoro-2-(trifluoromethyl)pyridine; 3-Fluoro-α,α,α-trifluoro-2-picoline; Pyridine, 3-fluoro-2-(trifluoromethyl)-; 886510-21-0
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-Trifluoromethylpyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA), including results from GC, HPLC, NMR, and moisture analysis, is supplied with each shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its high volatility and sensitivity to strong bases, keep away from heat, sparks, and open flames. The container must be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.