Description

3'-Methoxy-Biphenyl-3-Sulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, which enable it to act as a versatile electrophilic reagent for introducing the biphenyl sulfonamide moiety. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in medicinal chemistry programs targeting a range of biological pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, especially those containing biphenyl sulfonamide scaffolds common in kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonamide group contributes to biological activity.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials requiring sulfonamide linkages for specific properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs for the production of bespoke intermediates for client projects under cGMP or research-grade conditions.

Basic Information

Product Name	3'-Methoxy-Biphenyl-3-Sulfonyl Chloride
CAS No.	886502-46-1
Molecular Formula	C13H11ClO3S
Molecular Weight	282.74 g/mol
Synonyms	3'-(Methoxy)-[1,1'-biphenyl]-3-sulfonyl chloride; [1,1'-Biphenyl]-3-sulfonyl chloride, 3'-methoxy-; 3-Methoxybiphenyl-3'-sulfonyl chloride; 3'-Methoxy-1,1'-biphenyl-3-sulfonyl chloride; 3-(3-Methoxyphenyl)benzenesulfonyl chloride; Biphenyl-3-sulfonyl chloride, 3'-methoxy derivative
EINECS	Contact for details

Quality Control

Our 3'-Methoxy-Biphenyl-3-Sulfonyl Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for research and process chemistry. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.