Description

(2,3-Difluorophenyl)Methanesulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary commercial value lies in its role as a versatile sulfonylation reagent, enabling the introduction of the (2,3-difluorophenyl)methanesulfonyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients where the difluorophenyl group can modulate biological activity, lipophilicity, and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the difluorophenyl group enhances bioactivity.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology Probes: Acts as a reagent for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and CDMO companies offering bespoke synthesis services.

Basic Information

Product Name	(2,3-Difluorophenyl)Methanesulfonyl Chloride
CAS No.	886498-49-3
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	2,3-Difluorobenzylsulfonyl Chloride; (2,3-Difluorobenzyl)sulfonyl Chloride; α,2,3-Trifluoro-α-toluenesulfonyl Chloride; 1-(Chlorosulfonyl)methyl-2,3-difluorobenzene; 886498-49-3; (2,3-Difluorophenyl)methylsulfonyl Chloride
EINECS	Contact for details

Quality Control

Every batch of (2,3-Difluorophenyl)Methanesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.