Description

6-Ethoxy-5-Fluoronicotinaldehyde is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique molecular structure, which enables the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced properties. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atom can improve metabolic stability and bioavailability.
• Chemical Research: A versatile reagent for organic synthesis, enabling the introduction of both fluorine and aldehyde functional groups into complex molecules.
• Material Science Precursor: Potential starting material for the development of fluorinated liquid crystals or organic electronic materials.
• Cross-Coupling Reactions: The aldehyde group makes it suitable for further functionalization via reactions like reductive amination or condensation.

Basic Information

Product Name	6-Ethoxy-5-Fluoronicotinaldehyde
CAS No.	886372-69-6
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	5-Fluoro-6-ethoxypyridine-3-carbaldehyde; 3-Pyridinecarboxaldehyde, 5-fluoro-6-ethoxy-; 5-Fluoro-6-ethoxy-3-pyridinecarboxaldehyde; 6-Ethoxy-5-fluoropyridine-3-carbaldehyde; 5-Fluoro-6-ethoxynicotinaldehyde; 6-Ethoxy-5-fluoronicotinyl aldehyde; 886372-69-6
EINECS	Contact for details

Quality Control

Our 6-Ethoxy-5-Fluoronicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.