Description

4-Fluoro-Pyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a carboxylic acid group with a fluorine atom on the pyridine ring, makes it indispensable for creating novel compounds with tailored properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions and asymmetric synthesis.
• Material Science Research: Employed in the creation of advanced organic materials, such as liquid crystals and organic semiconductors, where fluorination modifies electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Fluoro-Pyridine-2-Carboxylic Acid
CAS No.	886371-78-4
Molecular Formula	C6H4FNO2
Molecular Weight	141.10 g/mol
Synonyms	2-Carboxy-4-fluoropyridine; 4-Fluoropicolinic Acid; 4-Fluoropyridine-2-carboxylic acid; 4-Fluoro-2-pyridinecarboxylic Acid; 2-Pyridinecarboxylic acid, 4-fluoro-; 4-Fluoropyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.