Description

n-Boc-1-(5-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethylamine is a high-purity, protected amine building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists requiring precise molecular architecture in complex organic syntheses. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the construction of advanced molecules for crop protection agents, leveraging the unique properties of the bromopyridine and trifluoroethylamine motifs.
• Peptide Mimetics & PROTACs: Serves as a versatile building block for creating peptide-like structures and Proteolysis-Targeting Chimeras (PROTACs) due to its protected amine functionality.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Acts as a precursor for functionalized polymers or organic electronic materials where the bromo group allows for further derivatization.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules to study biological pathways and interactions.

Basic Information

Product Name	n-Boc-1-(5-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethylamine
CAS No.	886368-08-7
Molecular Formula	C₁₂H₁₄BrF₃N₂O₂
Molecular Weight	355.15 g/mol
Synonyms	1-(5-Bromo-3-pyridinyl)-2,2,2-trifluoro-N-[(1,1-dimethylethoxy)carbonyl]ethanamine; tert-Butyl N-[1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethyl]carbamate; 5-Bromo-3-[(N-Boc-amino)(trifluoromethyl)methyl]pyridine; 1-(5-Bromo-3-pyridyl)-2,2,2-trifluoroethylamine N-Boc derivative; Boc-5-Bromo-3-(aminotrifluoroethyl)pyridine; N-Boc-1-(5-Bromo-3-pyridinyl)-2,2,2-trifluoroethylamine
EINECS	Contact for details

Quality Control

Our n-Boc-1-(5-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.