Description

1-(5-Bromo-3-Pyridinyl)-2,2,2-trifluoroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its bromopyridine and trifluoroacetyl functional groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate halogenated, fluorinated heterocycles into their molecular targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the bromine and fluorine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands and functional molecules used in catalysis and organic electronics.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological systems and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	1-(5-Bromo-3-Pyridinyl)-2,2,2-trifluoroethanone
CAS No.	886364-44-9
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.00 g/mol
Synonyms	5-Bromo-3-trifluoroacetylpyridine; 5-Bromo-3-pyridyl trifluoromethyl ketone; 1-(5-Bromo-3-pyridyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-bromopyridin-3-yl)ethanone; 5-Bromo-3-(trifluoroacetyl)pyridine; 3-Pyridinecarbonyl trifluoride, 5-bromo-; 5-Bromo-3-trifluoroacetylpyridine; 886364-44-9
EINECS	Contact for details

Quality Control

Our production of 1-(5-Bromo-3-Pyridinyl)-2,2,2-trifluoroethanone adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.