Description

3-[3,5-Bis(Trifluoromethyl)Phenyl]Benzenesulfonyl Chloride is a high-value, multi-fluorinated sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in introducing the highly lipophilic and electron-withdrawing bis(trifluoromethyl)phenyl group, which is essential for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly protease inhibitors, kinase inhibitors, and other small molecule therapeutics where the trifluoromethyl groups enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the introduced fluorinated aromatic system can improve efficacy and environmental profile.
• Material Science: Building block for functional polymers, liquid crystals, and organic electronic materials that require specific dielectric properties and chemical resistance.
• Chemical Biology Probes: Employed in the development of activity-based probes and covalent inhibitors for target identification and validation in biological systems.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl architectures.
• Sulfonamide Library Synthesis: Fundamental reagent for high-throughput parallel synthesis of diverse sulfonamide libraries for screening in drug discovery programs.

Basic Information

Product Name	3-[3,5-Bis(Trifluoromethyl)Phenyl]Benzenesulfonyl Chloride
CAS No.	885950-94-7
Molecular Formula	C14H7ClF6O2S
Molecular Weight	388.71 g/mol
Synonyms	3-[3,5-Bis(trifluoromethyl)phenyl]benzenesulfonyl chloride; [3,5-Bis(trifluoromethyl)phenyl]phenylsulfonyl chloride; 3,5-Bis(trifluoromethyl)benzenesulfonyl chloride benzene derivative; m-(3,5-Bis(trifluoromethyl)phenyl)benzenesulfonyl chloride; 1-Chlorosulfonyl-3-[3,5-bis(trifluoromethyl)phenyl]benzene; 3'-(3,5-Bis(trifluoromethyl)phenyl)benzenesulfonyl chloride; (3-(3,5-Bis(trifluoromethyl)phenyl)phenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-[3,5-Bis(Trifluoromethyl)Phenyl]Benzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (NMR, IR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent hydrolysis of the sulfonyl chloride group. Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.