Description

n-(12-Aminododecyl)-1-Deoxynojirimycin is a synthetic, nitrogen-containing glycosidase inhibitor derived from the 1-deoxynojirimycin (DNJ) scaffold, functionalized with a long-chain aminododecyl group. This structural modification enhances its lipophilicity and biological activity, making it a valuable intermediate for pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for investigating metabolic disorders and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced glycosidase inhibitors for potential drug candidates targeting diabetes, viral infections (e.g., HIV, hepatitis), and lysosomal storage diseases.
• Biochemical Research: Used as a potent and selective inhibitor in enzymatic studies to investigate carbohydrate metabolism pathways and glycoprotein processing.
• Antiviral Agent Development: Serves as a core structure for developing compounds that interfere with viral envelope glycoprotein maturation, showing promise in antiviral research.
• Glycobiology Tool: Essential reagent for probing the function of endoplasmic reticulum α-glucosidases I and II in cell-based assays and mechanistic studies.
• Preclinical Studies: Employed in animal models to evaluate the efficacy and pharmacokinetics of novel iminosugar-based therapeutics.

Basic Information

Product Name	n-(12-Aminododecyl)-1-Deoxynojirimycin
CAS No.	885484-41-3
Molecular Formula	C24H49N3O4
Molecular Weight	443.67 g/mol
Synonyms	12-Aminododecyl-DNJ; N-Dodecylamino-1-deoxynojirimycin; AD-DNJ; 1-Deoxynojirimycin, N-(12-aminododecyl)-; (2R,3R,4R,5S)-2-(Aminomethyl)-1-[(12-aminododecyl)amino]-1,3,4,5-tetrahydroxyhexane; N-(12-Amino-1-dodecyl)-1,5-dideoxy-1,5-imino-D-glucitol; Iminosugar C12-amine derivative
EINECS	Contact for details

Quality Control

Our n-(12-Aminododecyl)-1-Deoxynojirimycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.