Description

3'-(Trifluoromethyl)[1,1'-Biphenyl]-4-Sulfonyl Chloride CAS NO 885267-96-9 is a high-purity, specialized organic intermediate featuring a biphenyl core with sulfonyl chloride and trifluoromethyl substituents. This compound is a critical building block in modern pharmaceutical and agrochemical synthesis, valued for its ability to introduce the sulfonamide pharmacophore and the metabolically stable trifluoromethyl group. It is primarily sought after by research and development chemists and process scale-up teams in the life sciences industry for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and pesticides where the biphenyl-sulfonamide structure enhances biological activity and selectivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzymes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	3'-(Trifluoromethyl)[1,1'-Biphenyl]-4-Sulfonyl Chloride
CAS No.	885267-96-9
Molecular Formula	C₁₃H₈ClF₃O₂S
Molecular Weight	320.71 g/mol
Synonyms	[1,1'-Biphenyl]-4-sulfonyl chloride, 3'-(trifluoromethyl)-; 3'-(Trifluoromethyl)biphenyl-4-sulfonyl chloride; 4-(3-(Trifluoromethyl)phenyl)benzenesulfonyl chloride; 3-Trifluoromethyl-4'-sulfonylchlorobiphenyl; 3'-Trifluoromethylbiphenyl-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3'-(Trifluoromethyl)[1,1'-Biphenyl]-4-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) specifying purity (typically ≥97% by HPLC), identity confirmation, and impurity profile is supplied with each shipment to guarantee supply reliability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.