Description

Gw9508 is a potent and selective small molecule agonist for the GPR40 (G protein-coupled receptor 40), also known as Free Fatty Acid Receptor 1 (FFAR1). This compound is of significant interest for its role in modulating insulin secretion in a glucose-dependent manner, making it a valuable pharmacological tool for metabolic research. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on diabetes, metabolic syndrome, and novel therapeutic target validation.

Application

• Pharmacological Research Tool: Used extensively in in vitro and in vivo studies to investigate GPR40/FFAR1 signaling pathways and their physiological effects.
• Diabetes and Metabolic Disease Research: A key compound for studying glucose-stimulated insulin secretion (GSIS) and developing potential treatments for type 2 diabetes.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in screening assays designed to discover new GPR40 modulators.
• Biochemical Mechanism Studies: Employed to elucidate the downstream effects of GPR40 activation on pancreatic β-cell function and survival.
• Preclinical Development: Supports early-stage drug discovery programs aimed at developing next-generation GPR40-targeted therapeutics.

Basic Information

Product Name	Gw9508
CAS No.	885101-89-3
Molecular Formula	C₁₉H₁₈F₃NO₃
Molecular Weight	365.35 g/mol
Synonyms	GW-9508; GW 9508; 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid; 3-[4-[[(3-Phenoxyphenyl)methyl]amino]phenyl]propanoic acid; GPR40 agonist; FFAR1 agonist; Free Fatty Acid Receptor 1 agonist
EINECS	Contact for details

Quality Control

Our Gw9508 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC chromatograms and NMR spectra for identity confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.