Description

6-Fluoro-5-Iodopyridin-2-Ol is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides requiring specific halogenated motifs for bioactivity.
• Material Science Precursor: Employed in the synthesis of specialized ligands for catalysis and functional polymers.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination.
• Fluorine Chemistry: The fluorine atom provides metabolic stability and influences lipophilicity, making it valuable for optimizing pharmacokinetic properties in lead compounds.

Basic Information

Product Name	6-Fluoro-5-Iodopyridin-2-Ol
CAS No.	884660-48-4
Molecular Formula	C5H3FINO
Molecular Weight	254.98 g/mol
Synonyms	2-Hydroxy-6-fluoro-5-iodopyridine; 5-Iodo-6-fluoropyridin-2-ol; 6-Fluoro-5-iodo-2-pyridinol; 6-Fluoro-5-iodo-2(1H)-pyridinone; 2-Pyridinol, 6-fluoro-5-iodo-; 6-Fluoro-5-iodopyridin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 6-Fluoro-5-Iodopyridin-2-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.