Description

3-Amino-5-Bromo-2-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of amino, bromo, and fluoro substituents, which enable precise molecular modifications and the introduction of key pharmacophores. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Chemical Biology Probes: Utilized to create fluorescent tags, affinity probes, and other tools for biochemical research and diagnostics.

Basic Information

Product Name	3-Amino-5-Bromo-2-Fluoropyridine
CAS No.	884495-22-1
Molecular Formula	C5H4BrFN2
Molecular Weight	191.00 g/mol
Synonyms	5-Bromo-2-fluoro-3-pyridinamine; 2-Fluoro-5-bromo-3-aminopyridine; 3-Pyridinamine, 5-bromo-2-fluoro-; 5-Bromo-2-fluoropyridin-3-amine; 3-Amino-5-bromo-2-fluoropyridine; 2-Fluoro-3-amino-5-bromopyridine; 5-Bromo-2-fluoro-3-aminopyridine; 3-Amino-2-fluoro-5-bromopyridine
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Bromo-2-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.