Description

4-Fluoro-2-Nitropyridine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a fluorine atom on the pyridine ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its bioisosteric properties.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers and photoactive compounds.
• Fluorinated Compound Library: A valuable scaffold for medicinal chemistry to build diverse libraries of fluorinated compounds for high-throughput screening.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	4-Fluoro-2-Nitropyridine
CAS No.	884495-09-4
Molecular Formula	C5H3FN2O2
Molecular Weight	142.09 g/mol
Synonyms	2-Nitro-4-fluoropyridine; 4-Fluoro-2-nitropyridine; 4-Fluoropyridine, 2-nitro-; Pyridine, 4-fluoro-2-nitro-; 884495-09-4; 4-Fluoro-2-nitro-pyridine; 2-Nitro-4-fluoro-pyridine
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.