Description

5-Chloro-2-Fluoro-3-Pyridinemethanol is a high-value fluorinated pyridine derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents adjacent to a hydroxymethyl group, makes it indispensable for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-Pyridinemethanol
CAS No.	884494-79-5
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	(5-Chloro-2-fluoropyridin-3-yl)methanol; 3-Pyridinemethanol, 5-chloro-2-fluoro-; 5-Chloro-2-fluoro-3-hydroxymethylpyridine; 2-Fluoro-5-chloro-3-pyridinemethanol; 5-Chloro-2-fluoronicotinyl alcohol; 5-Chloro-2-fluoro-3-(hydroxymethyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-3-Pyridinemethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.