Description

2-Ethynyl-5-Fluoropyridine is a high-value, multi-functional pyridine derivative featuring both an ethynyl and a fluorine substituent. This unique structure makes it a critical pharmaceutical intermediate and a versatile building block for advanced organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries to construct complex molecules for drug discovery and specialty chemical applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its fluorine and pyridine motifs.
• Material Science Precursor: Serves as a monomer or linker in the development of advanced polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions to form conjugated systems.
• Click Chemistry: Acts as a component in Huisgen cycloaddition (click chemistry) reactions to rapidly assemble complex molecular architectures.
• Ligand & Catalyst Development: Used to synthesize novel nitrogen-containing ligands for transition metal catalysts.

Basic Information

Product Name	2-Ethynyl-5-Fluoropyridine
CAS No.	884494-34-2
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	5-Fluoro-2-ethynylpyridine; 2-Ethynyl-5-fluoropyridine; 5-Fluoro-2-pyridylacetylene; 2-Pyridylacetylene, 5-fluoro-; 5-Fluoropyridin-2-ylacetylene
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.