Description

(4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine CAS NO 883442-46-4 is a high-purity fluorinated heterocyclic amine building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, which combines a fluorine-substituted tetrahydropyran ring with a primary amine functional group, enabling precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom and amine group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, leveraging the stereogenic center and basic nitrogen.
• Material Science Research: Employed in the synthesis of specialty polymers, dendrimers, or functionalized surfaces where its fluorinated cyclic structure imparts specific physical properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes and tags for studying biological systems, benefiting from its potential for bio-conjugation and fluorination effects.
• Custom Fine Chemical Manufacturing: A versatile building block for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	(4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine
CAS No.	883442-46-4
Molecular Formula	C6H12FNO
Molecular Weight	133.16 g/mol
Synonyms	4-(Aminomethyl)-4-fluorotetrahydropyran; (4-Fluorotetrahydro-2H-pyran-4-yl)methylamine; 4-Fluoro-4-(aminomethyl)tetrahydro-2H-pyran; 4-Fluorotetrahydropyran-4-ylmethanamine; 4-(Aminomethyl)-4-fluorooxane; 4-Fluoro-4-(aminomethyl)oxane; 883442-46-4
EINECS	Contact for details

Quality Control

Our (4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high-purity building blocks under ISO 9001 guided standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.