Description

4-(1,1-Difluoropropan-2-Yl)Benzene-1-Sulfonyl Chloride is a high-purity, specialized organofluorine building block and sulfonylating agent. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of a sulfonyl chloride moiety and a difluorinated alkyl chain enables precise modulation of biological activity and physicochemical properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoroalkyl group can enhance metabolic stability and lipophilicity.
• Chemical Biology Probe Development: Serves as a versatile reagent for labeling proteins or other biomolecules via sulfonamide bond formation, useful in proteomics and drug discovery.
• Material Science Research: Employed in the creation of specialty polymers and functional materials that require sulfonyl chloride groups for further chemical modification.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-(1,1-Difluoropropan-2-Yl)Benzene-1-Sulfonyl Chloride
CAS No.	883146-12-1
Molecular Formula	C9H9ClF2O2S
Molecular Weight	254.68 g/mol
Synonyms	1-(1,1-Difluoropropan-2-yl)-4-sulfonylchloridebenzene; 4-(1,1-Difluoro-2-propyl)benzenesulfonyl chloride; 4-(1,1-Difluoropropan-2-yl)benzenesulfonyl chloride; p-(1,1-Difluoropropan-2-yl)benzenesulfonyl chloride; α,α-Difluoro-2-(4-(chlorosulfonyl)phenyl)propane; Benzene-1-sulfonyl chloride, 4-(1,1-difluoropropan-2-yl)-; 883146-12-1
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoropropan-2-Yl)Benzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.