Description

Hif-2A Translation Inhibitor 76 is a potent and selective small molecule inhibitor designed to target hypoxia-inducible factor 2 alpha (HIF-2α) translation. This compound matters for researchers and developers as it provides a critical tool for modulating the HIF signaling pathway, which is central to cellular adaptation to low oxygen and implicated in various disease states. It is essential for pharmaceutical R&D, academic research in oncology and metabolic disorders, and the development of novel therapeutics targeting conditions like renal cell carcinoma and polycythemia.

Application

• Biomedical Research: A key reagent for studying the role of the HIF-2α pathway in cellular response to hypoxia, angiogenesis, and iron metabolism.
• Oncology Drug Discovery: Used in target validation and screening assays for the development of novel cancer therapeutics, particularly for clear cell renal cell carcinoma (ccRCC).
• Pharmacology Studies: Employed in in vitro and in vivo models to investigate pharmacokinetics, efficacy, and mechanism of action of HIF-2α inhibition.
• Biochemical Assay Development: Serves as a reference standard in high-throughput screening (HTS) and enzyme-linked immunosorbent assays (ELISA) to identify and characterize new inhibitors.
• Academic Research: Utilized in universities and research institutes for fundamental studies on oxygen sensing, gene regulation, and related metabolic pathways.

Basic Information

Product Name	Hif-2A Translation Inhibitor 76
CAS No.	882268-69-1
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	HIF-2α Translation Inhibitor 76; PT2385 analog; HIF2A Inhibitor 76; 1-(5-Chloro-2-methoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea; 1-(5-Chloro-2-methoxyphenyl)-3-(5-methylisoxazol-3-yl)urea; BLL-2A-76; CAS 882268-69-1
EINECS	Contact for details

Quality Control

Our Hif-2A Translation Inhibitor 76 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical and academic research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.