Description

Succinylacetone CAS NO 881835-86-5 is a high-purity biochemical reagent and a potent, specific inhibitor of the enzyme 5-aminolevulinic acid dehydratase (ALAD). This compound matters for researchers and manufacturers as it is a critical tool for studying heme biosynthesis pathways and porphyria-related disorders. It is needed by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions focused on enzymology and metabolic disease research.

Application

• Biochemical Research: Used as a specific inhibitor in studies of the heme biosynthesis pathway, particularly to investigate the role of 5-aminolevulinic acid dehydratase (ALAD).
• Enzyme Inhibition Studies: Serves as a reference standard and tool compound for in vitro and in vivo models of ALAD inhibition.
• Diagnostic Development: Employed in the development and calibration of diagnostic assays for hereditary tyrosinemia type I (HT-1), where succinylacetone is a key biomarker.
• Pharmaceutical Intermediates: Acts as a specialized synthetic intermediate or reference molecule in the development of targeted therapeutics for metabolic diseases.
• Metabolic Disorder Modeling: Utilized to create cellular or animal models of porphyria and related disorders for pharmacological testing.
• Quality Control Standards: Functions as a high-purity certified reference material (CRM) for analytical laboratories performing clinical or forensic toxicology.

Basic Information

Product Name	Succinylacetone
CAS No.	881835-86-5
Molecular Formula	C6H8O3
Molecular Weight	128.13 g/mol
Synonyms	4,6-Dioxoheptanoic Acid; 1,4-Diacetylbutane-2-one; 5-Acetyl-4-oxopentanoic Acid; 4,6-Dioxoheptanoate; ALAD Inhibitor; NSC 163066; SA; Succinyl acetone
EINECS	Contact for details

Quality Control

Our Succinylacetone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.