Description

1-Tosyl-1H-Indole-3-Sulfonyl Chloride is a specialized sulfonyl chloride derivative of indole, serving as a critical building block in advanced organic synthesis. This compound matters for its dual reactive sites, enabling the selective introduction of the tosyl-protected indole sulfonyl moiety into complex molecular architectures. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Building block for creating specialized polymers, dyes, and photoactive compounds.
• Chemical Biology & Proteomics: Useful as a reagent for modifying peptides, proteins, or other biomolecules due to its sulfonyl chloride reactivity.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory chemistry.
• Scale-up & Process Chemistry: Serves as a starting material for optimizing synthetic routes from milligram to kilogram scale in pilot plants.

Basic Information

Product Name	1-Tosyl-1H-Indole-3-Sulfonyl Chloride
CAS No.	881406-30-0
Molecular Formula	C15H12ClNO4S2
Molecular Weight	369.84 g/mol
Synonyms	1H-Indole-3-sulfonyl chloride, 1-(4-methylphenyl)sulfonyl-; 1-Tosylindole-3-sulfonyl chloride; 1-(Tosyl)-1H-indole-3-sulfonyl chloride; 1-(4-Methylbenzenesulfonyl)-1H-indole-3-sulfonyl chloride; N-Tosyl-3-indolesulfonyl chloride; 881406-30-0; 1-Ts-indole-3-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Tosyl-1H-Indole-3-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.