Description

Aurora Kinase Inhibitor III is a potent and selective small-molecule inhibitor designed to target the Aurora family of serine/threonine kinases, which are critical regulators of cell division. This compound is a vital research tool for investigating mitotic progression, chromosome segregation, and the mechanisms of oncogenesis in various cancer cell lines. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Biochemical Research: Used as a key pharmacological agent to study the role of Aurora kinases (A, B, and C) in cell cycle regulation and mitosis.
• Oncology Drug Discovery: Serves as a reference standard and lead compound in the development of novel anti-cancer therapeutics targeting mitotic pathways.
• Cell Biology Studies: Employed to induce mitotic arrest and apoptosis in cultured cancer cells, facilitating the study of cell death mechanisms and checkpoint controls.
• Target Validation: A critical tool for validating Aurora kinases as therapeutic targets in various in vitro and in vivo disease models.
• High-Throughput Screening (HTS): Used as a control compound in screening assays to identify new kinase inhibitors or to profile compound selectivity.
• Mechanism of Action (MoA) Studies: Helps elucidate the downstream signaling pathways and phenotypic consequences of Aurora kinase inhibition.

Basic Information

Product Name	Aurora Kinase Inhibitor III
CAS No.	879127-16-9
Molecular Formula	C₂₁H₂₃N₅O₂S
Molecular Weight	409.51 g/mol
Synonyms	VX-680; Tozasertib; MK-0457; 4-{4-[(4-Methylpiperazin-1-yl)methyl]phenyl}-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide; Aurora A/B/C Kinase Inhibitor; Aurora Kinase Inhibitor VX-680; Benzamide, 4-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
EINECS	Contact for details

Quality Control

Our Aurora Kinase Inhibitor III is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.