Description

Az 628 CAS NO 878739-06-1 is a potent and selective small molecule inhibitor primarily targeting the Raf/MEK/ERK signaling pathway. This compound is crucial for researchers and developers in the life sciences sector, providing a critical tool for modulating cellular processes and studying disease mechanisms. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on oncology, inflammatory diseases, and signal transduction studies.

Application

• Biochemical Research: A key tool compound for studying the Raf/MEK/ERK (MAPK) signaling pathway in cell biology and molecular pharmacology.
• Pharmaceutical Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of targeted cancer therapies.
• Oncology Research: Investigated for its potential anti-proliferative effects in various cancer cell lines and preclinical models.
• Signal Transduction Studies: Employed to inhibit B-Raf and C-Raf kinases to elucidate their roles in cellular proliferation, differentiation, and survival.
• High-Throughput Screening (HTS): Serves as a control or benchmark compound in assay development and drug screening campaigns.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in kinase biology and disease pathology.

Basic Information

Product Name	Az 628
CAS No.	878739-06-1
Molecular Formula	C₂₀H₁₅F₂N₅O₂
Molecular Weight	395.36 g/mol
Synonyms	AZ-628; AZ628; N-(3-(2-(2-Fluorophenyl)pyrido[2,3-d]pyrimidin-7-yl)phenyl)-2,4-difluorobenzenesulfonamide; 2,4-Difluoro-N-[3-[2-(2-fluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]phenyl]benzenesulfonamide; B-Raf inhibitor AZ 628; Raf Kinase Inhibitor AZ628
EINECS	Contact for details

Quality Control

Our Az 628 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets high-purity standards for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.