Description

Pyridine-2-Sulfonyl Fluoride is a high-value, reactive organosulfur fluorinating agent. This compound is a critical building block in modern synthetic chemistry, prized for its role as a sulfonyl fluoride donor in click chemistry and SuFEx (Sulfur(VI) Fluoride Exchange) reactions. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating sulfonamide-based protease inhibitors and other bioactive molecules. Its unique reactivity profile enables efficient and selective late-stage functionalization of complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and kinase inhibitors.
• SuFEx Click Chemistry: Serves as a robust electrophile in Sulfur(VI) Fluoride Exchange reactions for the rapid and reliable construction of S(VI) linkages, useful in bioconjugation and polymer science.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate sulfonyl fluoride or sulfonamide moieties.
• Chemical Biology Probe Development: Employed to create activity-based probes (ABPs) for profiling enzyme activity, particularly serine hydrolases, due to its reactive sulfonyl fluoride warhead.
• Material Science: A monomer or cross-linking agent in the development of specialty polymers with unique surface properties or chemical resistance.
• Organic Synthesis Reagent: Utilized as a versatile reagent for introducing the pyridine-2-sulfonyl group into molecules, enabling further derivatization.

Basic Information

Product Name	Pyridine-2-Sulfonyl Fluoride
CAS No.	878376-35-3
Molecular Formula	C5H4FNO2S
Molecular Weight	161.16 g/mol
Synonyms	2-Pyridinesulfonyl Fluoride; Pyridine-2-sulfonylfluoride; 2-Pyridylsulfonyl Fluoride; 2-Sulfonylfluoropyridine; Pyridine-2-sulfonic Acid Fluoride; 2-Fluorosulfonylpyridine; 2-Pyridinesulfonic Acid Fluoride
EINECS	Contact for details

Quality Control

Our Pyridine-2-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.