Description

Benzothiazole-2-Sulfonyl Fluoride is a high-value organosulfur building block featuring a reactive sulfonyl fluoride group. This compound is critical for the synthesis of covalent inhibitors and probes in modern drug discovery and chemical biology. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted therapies and advanced materials.

Application

• Covalent Inhibitor Development: A key electrophilic warhead for creating irreversible inhibitors targeting serine, threonine, and cysteine proteases.
• Chemical Biology Probes: Used in activity-based protein profiling (ABPP) to label and study enzyme function in complex biological systems.
• Pharmaceutical Intermediates: Serves as a versatile synthon for constructing benzothiazole-containing drug candidates with enhanced binding properties.
• Material Science: Employed in the synthesis of functional polymers and advanced materials where the sulfonyl fluoride moiety enables specific cross-linking or surface modification.
• Agrochemical Research: Acts as an intermediate in the design of novel herbicides and fungicides with specific modes of action.

Basic Information

Product Name	Benzothiazole-2-Sulfonyl Fluoride
CAS No.	878376-34-2
Molecular Formula	C7H4FNO2S2
Molecular Weight	217.24 g/mol
Synonyms	2-Benzothiazolesulfonyl Fluoride; 1,3-Benzothiazole-2-sulfonyl Fluoride; BT-Sulfonyl Fluoride; 2-Sulfonylfluoride Benzothiazole; Benzothiazole-2-sulfonylfluoride; 2-(Fluorosulfonyl)benzothiazole; BTSF
EINECS	Contact for details

Quality Control

Our Benzothiazole-2-Sulfonyl Fluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in regulated and non-regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Handle and store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.