Description

Butanedioic-13C4 Acid 1-Methyl Ester is a stable isotope-labeled derivative of succinic acid monomethyl ester, where all four carbon atoms are the carbon-13 (13C) isotope. This compound is an essential internal standard and tracer in quantitative mass spectrometry, enabling precise metabolic flux analysis and pharmacokinetic studies. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for advanced analytical and diagnostic applications.

Application

• Quantitative Mass Spectrometry (MS): Serves as a critical internal standard for the accurate quantification of endogenous succinate and related metabolites in complex biological matrices.
• Metabolic Pathway Analysis: Used as a 13C-labeled tracer to study the TCA cycle, gluconeogenesis, and other central carbon metabolic fluxes in cell cultures, tissues, and whole organisms.
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetics (DMPK) studies by tracking the fate of drug molecules and their metabolites.
• Clinical Diagnostics: Enables the development of highly specific and sensitive LC-MS/MS assays for diagnosing inborn errors of metabolism related to succinate dehydrogenase complex deficiencies.
• Biotechnology & Fermentation Monitoring: Applied in process analytics to monitor and optimize microbial production of organic acids and other bio-based chemicals.
• Environmental & Food Safety Testing: Enhances the accuracy of residue analysis for contaminants and toxins when used as a labeled analog in isotope dilution methods.

Basic Information

Product Name	Butanedioic-13C4 Acid 1-Methyl Ester
CAS No.	878205-29-9
Molecular Formula	13C4H8O4
Molecular Weight	136.07 (based on 13C)
Synonyms	Succinic-13C4 Acid Monomethyl Ester; Monomethyl Succinate-13C4; Methyl Hydrogen Succinate-13C4; 1-Methyl Butanedioate-13C4; Methyl 3-carboxypropanoate-13C4; (3-Methoxy-3-oxopropyl)carboxylic Acid-13C4; 13C4-Labeled Methyl Succinate
EINECS	Contact for details

Quality Control

Our Butanedioic-13C4 Acid 1-Methyl Ester is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to relevant standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
13C Isotopic Enrichment	≥99 atom %
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.