Description

Tw-37 is a high-purity, small-molecule chemical compound with significant utility in advanced research and development. This compound is valued for its role as a potent and selective inhibitor of Bcl-2 family proteins, which are key regulators of apoptosis. It is primarily utilized by researchers in the pharmaceutical, biotechnology, and life sciences sectors for target validation, mechanism-of-action studies, and as a critical reference standard in drug discovery pipelines.

Application

• Biomedical Research: A key tool compound for studying programmed cell death (apoptosis) pathways and cancer biology.
• Drug Discovery & Development: Used as a reference standard and positive control in high-throughput screening (HTS) assays targeting anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the therapeutic potential of modulating apoptosis for oncology applications.
• Biochemical Assay Development: Serves as a critical component in developing and validating fluorescence polarization (FP), ELISA, or other binding assays for Bcl-2 family protein interactions.
• Academic Research: Supports fundamental research in cell biology, biochemistry, and molecular pharmacology at universities and research institutes.

Basic Information

Product Name	Tw-37
CAS No.	877877-35-5
Molecular Formula	C38H44N4O6S
Molecular Weight	684.85 g/mol
Synonyms	TW-37; TW 37; N-[4-[[2-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)ethyl]amino]-3-nitrophenyl]methanesulfonamide; Benz[de]isoquinoline-1,3-dione, 2-[2-[[4-(methylsulfonyl)-2-nitrophenyl]amino]ethyl]-; Bcl-2 Inhibitor TW-37; Apoptosis Inhibitor TW-37
EINECS	Contact for details

Quality Control

Every batch of Tw-37 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with our rigorous in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.