Description

1H-Imidazole-2-Sulfonyl Chloride Hydrochloride is a high-purity, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. This compound is valued for its role in introducing the imidazole-2-sulfonyl moiety, enabling the construction of complex molecules with specific functional properties. It is primarily sought by research and development laboratories, as well as process chemists, in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly those targeting enzymes or receptors where the imidazole-sulfonamide pharmacophore is relevant.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactivity to create novel compound libraries.
• Chemical Biology & Proteomics: Serves as a reagent for chemical probe development and activity-based protein profiling (ABPP) due to its electrophilic sulfonyl chloride group.
• Material Science Research: Employed in the synthesis of functionalized polymers or organic frameworks that incorporate heterocyclic sulfonamide linkages.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Item	Detail
Product Name	1H-Imidazole-2-Sulfonyl Chloride Hydrochloride
CAS No.	877861-76-2
Molecular Formula	C3H4Cl2N2O2S
Molecular Weight	227.05 g/mol
Synonyms	1H-Imidazole-2-sulfonyl chloride, hydrochloride; Imidazole-2-sulfonyl chloride hydrochloride; 2-Imidazolesulfonyl chloride hydrochloride; 1H-Imidazole-2-sulfonic acid chloride hydrochloride; 2-(Chlorosulfonyl)-1H-imidazole hydrochloride
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-2-Sulfonyl Chloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.