Description

Iwp-2-V2 is a high-purity, small molecule compound with the CAS registry number 877618-79-6, widely recognized as a potent and selective inhibitor of the Wnt/β-catenin signaling pathway. This compound matters for researchers and developers in the life sciences sector as it provides a critical tool for modulating a key cellular pathway involved in cell proliferation, differentiation, and stem cell maintenance. Pharmaceutical, biotechnology, and academic research institutions need it for advanced studies in oncology, regenerative medicine, and developmental biology, where precise pathway inhibition is required.

Application

• Biomedical Research: Used as a key pharmacological tool to study the role of the Wnt/β-catenin pathway in various disease models, including cancer and tissue regeneration.
• Drug Discovery & Development: Serves as a reference standard and lead compound in high-throughput screening and the development of novel targeted cancer therapies.
• Stem Cell Research: Applied in *in vitro* studies to control stem cell fate, differentiation, and self-renewal by inhibiting canonical Wnt signaling.
• Oncology Research: Utilized to investigate tumorigenesis, cancer cell proliferation, and metastasis in preclinical models of colorectal, breast, and liver cancers.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental and applied research in cell signaling pathways.
• Biochemical Assay Development: Employed as a control inhibitor in developing and validating cell-based and biochemical assays for drug screening.

Basic Information

Product Name	Iwp-2-V2
CAS No.	877618-79-6
Molecular Formula	C₂₀H₁₈N₄O₃
Molecular Weight	362.38 g/mol
Synonyms	IWP-2; IWP 2; IWP2; IWP-2 V2; 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-4-yl)phenyl)acetamide; Wnt Pathway Inhibitor II; Porcupine Inhibitor IWP-2; (2E)-3-(2,4-Dichlorophenyl)-2-cyano-N-(5-phenylthiazol-2-yl)acrylamide (common mis-association corrected); LGK974 analog (research context)
EINECS	Contact for details

Quality Control

Our Iwp-2-V2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.