Description

5-Bromo-2-Fluoropyridine-3-Carboxaldehyde is a versatile and high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents adjacent to an aldehyde group, makes it an exceptionally valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated pyridine motifs.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up development.

Basic Information

Product Name	5-Bromo-2-Fluoropyridine-3-Carboxaldehyde
CAS No.	875781-15-0
Molecular Formula	C6H3BrFNO
Molecular Weight	204.00 g/mol
Synonyms	5-Bromo-2-fluoropyridine-3-carbaldehyde; 3-Formyl-5-bromo-2-fluoropyridine; 2-Fluoro-5-bromonicotinaldehyde; 875781-15-0; 5-Bromo-2-fluoro-3-pyridinecarboxaldehyde; 5-Bromo-2-fluoronicotinaldehyde; 2-Fluoro-5-bromo-3-pyridinecarbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Fluoropyridine-3-Carboxaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our products are supplied with comprehensive documentation, including a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as confirmed by HPLC, GC, NMR, and IR spectroscopy. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and reliability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.