Description

1,3-Dioxane-2-Ethanesulfonyl Chloride is a specialized sulfonyl chloride derivative featuring a protected aldehyde functionality within the 1,3-dioxane ring. This compound is a high-value synthetic intermediate prized for its dual reactivity, serving as a key electrophile for introducing sulfonyl groups and a masked aldehyde precursor. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonyl moiety is essential for biological activity.
• Material Science Research: Employed in the creation of functional polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Serves as a reagent for modifying proteins or other biomolecules to study function or create conjugates.
• Organic Synthesis: Acts as a versatile electrophile in nucleophilic substitution reactions and as a precursor for generating aldehydes under mild acidic conditions.

Basic Information

Product Name	1,3-Dioxane-2-Ethanesulfonyl Chloride
CAS No.	874979-34-7
Molecular Formula	C6H11ClO4S
Molecular Weight	214.67 g/mol
Synonyms	2-(Chlorosulfonyl)ethyl 1,3-Dioxane; 1,3-Dioxan-2-ylethanesulfonyl chloride; 2-(1,3-Dioxan-2-yl)ethanesulfonyl chloride; Ethanesulfonyl chloride, 2-(1,3-dioxan-2-yl)-; 2-(1,3-Dioxan-2-yl)ethylsulfonyl chloride; (1,3-Dioxan-2-yl)methanesulfonyl chloride (related isomer); 874979-34-7
EINECS	Contact for details

Quality Control

Every batch of 1,3-Dioxane-2-Ethanesulfonyl Chloride is produced and tested under strict quality management protocols. We ensure high purity and consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.