Description

4-[2-(Methylthio)Pyrimidin-4Yl]Thiophene-2-Sulfonyl Chloride is a high-value, multi-functional heterocyclic building block and key synthetic intermediate. Its core value lies in its reactive sulfonyl chloride group, which enables efficient derivatization for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of kinase inhibitors, antiviral agents, and other small molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its conjugated thiophene-pyrimidine system.
• Chemical Biology: Employed in the design and synthesis of activity-based probes (ABPs) and molecular tags for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specific sulfonamide or sulfonate functionalities.
• Academic & R&D: Utilized in university and institutional laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	4-[2-(Methylthio)Pyrimidin-4Yl]Thiophene-2-Sulfonyl Chloride
CAS No.	874841-65-3
Molecular Formula	C10H7ClN2O2S3
Molecular Weight	318.82 g/mol
Synonyms	4-[2-(Methylsulfanyl)pyrimidin-4-yl]thiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 4-[2-(methylthio)-4-pyrimidinyl]-; 4-(2-(Methylthio)pyrimidin-4-yl)thiophene-2-sulfonyl chloride; 4-[2-(Methylmercapto)pyrimidin-4-yl]thiophene-2-sulfonyl chloride; 4-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophene-2-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-[2-(Methylthio)Pyrimidin-4Yl]Thiophene-2-Sulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.