Description

4-{[5-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and versatile chemical building block. Its core value lies in its reactive sulfonyl chloride group and unique trifluoromethylpyridine ether structure, making it a critical precursor for synthesizing complex molecules with enhanced biological activity and metabolic stability. This compound is essential for research and development chemists in the agrochemical and pharmaceutical industries, particularly for creating novel active ingredients in crop protection and drug discovery programs. Its precise structure enables the introduction of key pharmacophores into target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring sulfonamide or sulfonylurea motifs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances lipophilicity and biological activity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling, cross-linking, or modifying biomolecules in research applications due to its electrophilic sulfonyl chloride functionality.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	4-{[5-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride
CAS No.	874838-96-7
Molecular Formula	C12H7ClF3NO3S
Molecular Weight	337.70 g/mol
Synonyms	4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonyl chloride; 2-[(4-Chlorosulfonyl)phenoxy]-5-(trifluoromethyl)pyridine; 4-[(5-Trifluoromethyl-2-pyridyl)oxy]benzenesulfonyl chloride; 4-((5-(Trifluoromethyl)-2-pyridinyl)oxy)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-
EINECS	Contact for details

Quality Control

Every batch of 4-{[5-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Benzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for advanced intermediates. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.