Description

3-Bromo-2,4-Difluorobenzene-1-Sulfonyl Chloride is a high-purity, multi-functional aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites—the sulfonyl chloride and halogenated aromatic ring—which enable precise molecular construction for complex target compounds. This intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides that require specific halogen and sulfonyl functional groups for bioactivity.
• Material Science: Employed in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination.
• Sulfonylation Agent: The reactive sulfonyl chloride group is used to introduce the sulfonyl moiety into amines and alcohols to create sulfonamides and sulfonate esters.

Basic Information

Product Name	3-Bromo-2,4-Difluorobenzene-1-Sulfonyl Chloride
CAS No.	874804-10-1
Molecular Formula	C6H2BrClF2O2S
Molecular Weight	291.50 g/mol
Synonyms	3-Bromo-2,4-difluorobenzenesulfonyl chloride; 2,4-Difluoro-3-bromobenzenesulfonyl chloride; 1-Bromo-2,4-difluoro-6-(chlorosulfonyl)benzene; Benzenesulfonyl chloride, 3-bromo-2,4-difluoro-; 874804-10-1; 3-Br-2,4-F2-PhSO2Cl
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-2,4-Difluorobenzene-1-Sulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, amines, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.