Description

5-Chloro-2-Fluoro-4-Methylbenzenesulfonyl Chloride is a high-purity, multi-functional sulfonyl chloride derivative essential for advanced organic synthesis. This compound serves as a critical building block for introducing the sulfonamide moiety, enabling the development of novel molecules with tailored properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides by forming sulfonamide linkages in active molecules.
• Material Science Research: Employed in the development of specialty polymers, dyes, and functional materials requiring sulfonated aromatic structures.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or modifying biomolecules in proteomics and drug discovery research.
• Custom Synthesis & Contract Manufacturing: A versatile reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse client projects.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Methylbenzenesulfonyl Chloride
CAS No.	874801-53-3
Molecular Formula	C7H5Cl2FO2S
Molecular Weight	243.08 g/mol
Synonyms	4-Methyl-5-chloro-2-fluorobenzenesulfonyl chloride; 2-Fluoro-5-chloro-4-methylbenzenesulfonyl chloride; 5-Chloro-2-fluoro-p-toluenesulfonyl chloride; 1-Chloro-4-fluoro-5-methyl-2-sulfonyl chloride benzene; Benzenesulfonyl chloride, 5-chloro-2-fluoro-4-methyl-; 874801-53-3
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluoro-4-Methylbenzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A detailed Certificate of Analysis (COA) documenting purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.