Description

2-Bromo-5-Fluoro-4-Methylbenzenesulfonyl Chloride is a high-purity, multi-functional sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its reactive sulfonyl chloride group, which enables efficient introduction of the sulfonamide moiety, a key pharmacophore in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, antibacterial agents, and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides where the sulfonamide group contributes to biological activity.
• Material Science Research: Acts as a monomer or cross-linking agent in the creation of specialty polymers and functional materials.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production of complex organic molecules.

Basic Information

Item	Details
Product Name	2-Bromo-5-Fluoro-4-Methylbenzenesulfonyl Chloride
CAS No.	874801-51-1
Molecular Formula	C7H5BrClFO2S
Molecular Weight	287.53 g/mol
Synonyms	4-Methyl-2-bromo-5-fluorobenzenesulfonyl chloride; 2-Bromo-5-fluoro-4-methylbenzene-1-sulfonyl chloride; 5-Fluoro-2-bromo-4-methylbenzenesulfonyl chloride; 874801-51-1; Benzenesulfonyl chloride, 2-bromo-5-fluoro-4-methyl-; 2-Bromo-5-fluoro-p-toluenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoro-4-Methylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and strong acid/organic solvent nature, the container must be kept tightly sealed to exclude moisture and stored separately from bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.