Description

2-Bromo-4-Chloro-5-Fluorobenzenesulfonyl Chloride is a high-value, multi-halogenated benzenesulfonyl chloride derivative that serves as a critical synthetic building block in advanced organic chemistry. Its primary value lies in its versatile reactivity, where the sulfonyl chloride group acts as an excellent electrophile for introducing the sulfonamide or sulfonate moiety into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel active ingredients, particularly those requiring structurally diverse sulfonamide-based scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the halogenated sulfonamide structure contributes to biological activity and selectivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes to study enzyme activity and protein function.
• Dye & Pigment Manufacturing: Intermediate for synthesizing specialized sulfonated dyes and colorants with enhanced properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	2-Bromo-4-Chloro-5-Fluorobenzenesulfonyl Chloride
CAS No.	874801-47-5
Molecular Formula	C6H2BrCl2FO2S
Molecular Weight	312.40 g/mol
Synonyms	2-Bromo-4-chloro-5-fluorobenzenesulfonyl chloride; 5-Fluoro-2-bromo-4-chlorobenzenesulfonyl chloride; Benzenesulfonyl chloride, 2-bromo-4-chloro-5-fluoro-; 874801-47-5; 2-Bromo-4-chloro-5-fluoro-1-sulfonyl chloride benzene; 1-Bromo-3-chloro-4-fluoro-6-(chlorosulfonyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Chloro-5-Fluorobenzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to support regulatory filings for our customers in advanced markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.