Description

2-Methyl-6-(Trifluoromethyl)Nicotinamide is a high-value, fluorinated nicotinamide derivative characterized by its unique trifluoromethyl-substituted pyridine core. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Used in the development of specialty chemicals, liquid crystals, and functional materials due to its unique electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, amide bond formations, and as a scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• Biochemical Tool Compound: Potential use in biochemical assays and as a probe for studying enzyme interactions related to nicotinamide pathways.

Basic Information

Product Name	2-Methyl-6-(Trifluoromethyl)Nicotinamide
CAS No.	874767-59-6
Molecular Formula	C8H7F3N2O
Molecular Weight	204.15 g/mol
Synonyms	2-Methyl-6-(trifluoromethyl)pyridine-3-carboxamide; 3-Carbamoyl-2-methyl-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-2-methylnicotinamide; 2-Methyl-6-trifluoromethylnicotinamide; 2-Methyl-6-(trifluoromethyl)-3-pyridinecarboxamide; Nicosamide derivative; TFM Nicotinamide
EINECS	Contact for details

Quality Control

Our 2-Methyl-6-(Trifluoromethyl)Nicotinamide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.