Description

n-Desmethyl Dextrorphan-D3 is a deuterium-labeled internal standard of the pharmacologically active metabolite of dextromethorphan. This compound is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise and stable isotope-labeled reference materials for LC-MS/MS analysis.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of dextrorphan and related metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and drug metabolism studies for drugs metabolized through the CYP2D6 pathway.
• Enhances data accuracy in clinical research and forensic toxicology assays monitoring dextromethorphan abuse or compliance.
• Supports method development and validation in bioanalytical laboratories within pharmaceutical companies and CROs.
• Used in research investigating the pharmacology and neuroprotective effects of σ-1 receptor ligands.
• Facilitates high-precision doping control analysis in sports medicine.

Basic Information

Product Name	n-Desmethyl Dextrorphan-D3
CAS No.	873691-34-0
Molecular Formula	C17H20D3NO
Molecular Weight	260.39 g/mol
Synonyms	(+)-3-Hydroxy-N-methylmorphinan-D3; Dextrorphan-D3 metabolite; 17-(Methyl-d3)-9α,13α,14α-morphinan-3-ol; 3-Hydroxy-N-methylmorphinan-D3; Dextrorphan D3; d3-Dextrorphan; Nor-Dextrorphan-D3; (+)-3-Hydroxy-N-(trideuteriomethyl)morphinan
EINECS	Contact for details

Quality Control

Our n-Desmethyl Dextrorphan-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and other critical parameters. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D3)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.