Description

Tak-683 is a high-purity specialty chemical compound widely utilized as a key intermediate in the synthesis of advanced pharmaceuticals and agrochemicals. Its structural precision and batch-to-batch consistency make it critical for applications demanding strict stereochemical control and regulatory compliance. Pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical manufacturers rely on Tak-683 CAS NO 872719-49-8 for scalable, reproducible synthesis of bioactive molecules.

Application

• Intermediate in the synthesis of selective kinase inhibitors for oncology therapeutics
• Building block for next-generation herbicidal active ingredients with improved environmental persistence profiles
• Chiral scaffold in asymmetric catalysis for enantioselective C–N bond formation
• Key reagent in the preparation of proteolysis-targeting chimeras (PROTACs)
• Component in the development of radiolabeled tracers for PET imaging agents
• Functional monomer in specialty polymer synthesis for controlled-release drug delivery systems

Basic Information

Product Name	Tak-683
CAS No.	872719-49-8
Molecular Formula	C15H12F3N3O2
Molecular Weight	339.27 g/mol
Synonyms	3-(Trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; TAK-683; TAK683; 4-Amino-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidine; Pyrazolopyrimidine derivative TAK-683; CAS 872719-49-8; TAK 683; 3-CF3-4-NH2-pyrazolo[3,4-d]pyrimidine
EINECS	Not listed (not yet assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to ISO 9001-certified manufacturing protocols and meet stringent purity requirements for pharmaceutical intermediates (≥99.5% by HPLC). Testing includes identification (IR, NMR), assay, residual solvents (GC), heavy metals (ICP-MS), and water content (Karl Fischer). Compliant with REACH and subject to full traceability per batch.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccated storage conditions during long-term handling. Avoid contact with strong acids or organic solvents unless under controlled reaction conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (by HPLC)	≥99.5%
Related Substances (HPLC)	≤0.5% total impurities
Water (Karl Fischer)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.