Description

Zacopride Hydrochloride is a high-purity, selective pharmacological agent primarily known for its potent and specific antagonistic activity at the 5-HT3 receptor. This compound is crucial for research and development in neuropharmacology and gastroenterology, serving as a key reference standard and active pharmaceutical ingredient (API) intermediate. It is essential for pharmaceutical manufacturers, academic research institutions, and contract research organizations (CROs) focused on developing treatments for chemotherapy-induced nausea and vomiting (CINV), irritable bowel syndrome (IBS), and central nervous system disorders.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in API and finished drug product manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical building block in the synthesis of advanced therapeutic agents targeting serotonin receptors.
• Neuropharmacological Research: A vital tool for in vitro and in vivo studies investigating the role of 5-HT3 receptors in the central and peripheral nervous systems.
• Gastrointestinal Drug Development: Employed in R&D for novel therapeutics aimed at managing emesis, gastroesophageal reflux disease (GERD), and functional gut disorders.
• Preclinical Studies: Used in animal models to evaluate efficacy, pharmacokinetics, and safety profiles of potential antiemetic and prokinetic drugs.
• Biochemical Assay Development: Serves as a ligand in receptor binding assays and high-throughput screening (HTS) platforms.

Basic Information

Item	Detail
Product Name	Zacopride Hydrochloride
CAS No.	101303-98-4
Molecular Formula	C20H28N4O3 • HCl
Molecular Weight	424.92 g/mol
Synonyms	Zacopride HCl; 4-Amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide Hydrochloride; AH-11134A; Zacopride Monohydrochloride; 5-Chloro-2-methoxy-4-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]aniline Hydrochloride; Benzamide, 4-amino-5-chloro-N-(1-azabicyclo[2.2.2]oct-3-yl)-2-methoxy-, monohydrochloride
EINECS	Contact for details

Quality Control

Our Zacopride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and impurities to meet research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Long-term storage under inert atmosphere is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.