Description

Proglumide is a non-selective cholecystokinin (CCK) receptor antagonist with a well-defined chemical structure. This compound is a valuable research-grade chemical for investigating gastrointestinal physiology, pancreatic function, and central nervous system signaling pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity biochemical reagents.

Application

• Pharmacological Research: Used as a standard CCK receptor antagonist in in vitro and in vivo studies to explore digestive processes, satiety, and anxiety-related behaviors.
• Biochemical Assay Development: Serves as a key reference compound and competitive inhibitor in the development and validation of receptor binding assays.
• Academic & Clinical Studies: Employed in university and hospital laboratories to investigate the role of CCK in pain modulation, pancreatitis, and gastrointestinal motility disorders.
• Pharmaceutical Intermediates: Acts as a critical synthetic intermediate or precursor in the research-scale production of more complex therapeutic agents targeting CCK pathways.
• High-Purity Reference Standards: Supplied as a certified reference material (CRM) for analytical method development and quality control in regulatory environments.

Basic Information

Product Name	Proglumide
CAS No.	6620-60-6
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	4-Benzamido-N,N-dipropylglutaramic acid; CR 1409; DL-4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid; N-(α-PropyI-DL-glutamyl)-p-aminobenzamide; Milid; Gastridine; Xylamide; Proglumetacin (related compound)
EINECS	229-567-5

Quality Control

Our Proglumide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by IR spectroscopy, purity determination by HPLC, and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.