Description

trans-Cisapride is a high-purity, stereoisomeric form of the gastroprokinetic agent cisapride. This specific isomer is of significant interest in pharmaceutical research and development for its distinct pharmacological profile. It serves as a critical reference standard and intermediate for analytical method development, impurity profiling, and metabolic studies. Key industries requiring this compound include pharmaceutical R&D, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of cisapride and related compounds in HPLC, LC-MS, and other chromatographic systems.
• Impurity Profiling: Essential for identifying and quantifying the trans-isomer as a potential impurity in batches of cisapride API to ensure product purity and compliance.
• Metabolite Studies: Employed in research to study the metabolism, pharmacokinetics, and degradation pathways of cisapride.
• Chemical Intermediate: Acts as a building block in the synthetic pathways for novel gastroprokinetic agents or related chemical entities.
• Academic & Institutional Research: Utilized in universities and research institutes for pharmacological studies investigating serotonin (5-HT4) receptor interactions.
• Quality Control Laboratories: Serves as a critical component in the method validation and routine quality testing of pharmaceutical products containing cisapride.

Basic Information

Product Name	trans-Cisapride
CAS No.	104860-66-4
Molecular Formula	C23H29ClFN3O4
Molecular Weight	465.95 g/mol
Synonyms	trans-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide; (3R*,4R*)-Cisapride; (R*,R*)-Cisapride; trans Isomer of Cisapride; UNII-1U8M5M8KQE; 1U8M5M8KQE; (3R,4R)-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
EINECS	Contact for details

Quality Control

Our trans-Cisapride is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assay, stereoisomeric purity determination, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
trans-Isomer Content	≥ 99.0% (by chiral HPLC)
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.