Description

3-Ethynyl-5-Fluoropyridine is a high-value, multi-functional heterocyclic building block featuring both a fluoropyridine core and a terminal alkyne group. This unique molecular architecture makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the bioactivity of the fluoropyridine moiety.
• Material Science Building Block: Employed in the synthesis of conductive polymers, metal-organic frameworks (MOFs), and advanced organic electronic materials via Sonogashira and other cross-coupling reactions.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Click Chemistry Substrate: The terminal alkyne group is highly reactive in Huisgen cycloaddition (click chemistry) for bioconjugation and polymer functionalization.
• Chemical Biology Probe Synthesis: Used to create tagged molecules for studying biological processes and target engagement.

Basic Information

Item	Details
Product Name	3-Ethynyl-5-Fluoropyridine
CAS No.	872122-54-8
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	5-Fluoro-3-ethynylpyridine; 3-Ethynyl-5-fluoropyridine; 5-Fluoro-3-pyridylacetylene; 3-Pyridylacetylene, 5-fluoro-; 872122-54-8; 5-Fluoropyridin-3-ylacetylene
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-5-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. The compound is light-sensitive and easily oxidized.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/GC-MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.