Description

Gsk-3Beta Inhibitor Xxvi (Gsk-3B) is a potent and selective small-molecule inhibitor of glycogen synthase kinase-3 beta (GSK-3β), a key serine/threonine kinase involved in numerous cellular signaling pathways. This compound is a critical research tool for investigating the role of GSK-3β in diseases such as neurodegenerative disorders, diabetes, and cancer. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis. The high specificity of this inhibitor makes it invaluable for target validation and mechanistic studies.

Application

• Drug Discovery & Development: Used as a lead compound or reference standard in the development of novel therapeutics targeting GSK-3β for conditions like Alzheimer's disease, diabetes, and mood disorders.
• Academic & Biomedical Research: A key reagent for studying Wnt/β-catenin signaling, insulin signaling, and tau protein phosphorylation in cellular and animal models.
• Oncology Research: Employed to investigate the role of GSK-3β in tumor cell proliferation, survival, and chemoresistance.
• Neurodegenerative Disease Research: Essential for exploring mechanisms in Alzheimer's, Parkinson's, and other tauopathies.
• Metabolic Disorder Studies: Applied in research focused on insulin resistance, glucose metabolism, and type 2 diabetes.
• Stem Cell Research: Used to modulate signaling pathways that control stem cell self-renewal and differentiation.
• Biochemical Assay Development: Serves as a control inhibitor in high-throughput screening (HTS) and kinase activity assays.
• Preclinical Pharmacology: Utilized in pharmacokinetic and pharmacodynamic studies to evaluate efficacy in disease models.

Basic Information

Product Name	Gsk-3Beta Inhibitor Xxvi (Gsk-3B)
CAS No.	871843-09-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GSK-3β Inhibitor XXVI; GSK-3B Inhibitor; GSK3β Inhibitor 12; 6-Bromoindirubin-3'-oxime analog; BIO-based inhibitor; ATP-competitive GSK-3 inhibitor; AR-A014418 derivative; Kinase inhibitor for GSK-3β
EINECS	Contact for details

Quality Control

Our Gsk-3Beta Inhibitor Xxvi is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure high batch-to-batch consistency and compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.