Description

2-(Aminomethyl)-5-(Trifluoromethyl)Pyridine Hydrochloride is a high-value, functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both an aminomethyl group and a trifluoromethyl substituent, makes it a versatile intermediate for introducing key pharmacophores and modifying physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients. Its CAS number is 871826-12-9.

Application

This specialized intermediate is engineered for precision applications in research-driven sectors. Its primary uses include:

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed in the design of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Material Science Research: A building block for synthesizing functionalized polymers and advanced organic electronic materials.

Basic Information

Product Name	2-(Aminomethyl)-5-(Trifluoromethyl)Pyridine Hydrochloride
CAS No.	871826-12-9
Molecular Formula	C7H8ClF3N2
Molecular Weight	212.60 g/mol
Synonyms	5-(Trifluoromethyl)-2-pyridinemethanamine hydrochloride; 2-(Aminomethyl)-5-(trifluoromethyl)pyridine HCl; (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride; 2-Pyridinemethanamine, 5-(trifluoromethyl)-, hydrochloride; 871826-12-9; 2-Aminomethyl-5-trifluoromethylpyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Aminomethyl)-5-(Trifluoromethyl)Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.