Description

5-(1,3-Dioxolan-2-Yl)Thiophene-2-Sulfonyl Chloride is a high-value, multi-functional chemical building block primarily used in advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials due to its reactive sulfonyl chloride group and protected aldehyde functionality. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce thiophene-sulfonamide or sulfonate moieties into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Used in the development of organic semiconductors, conductive polymers, and advanced functional materials.
• Chemical Research: Versatile reagent for constructing complex heterocyclic compounds and for use in cross-coupling reactions.
• Scale-Up & Process Development: Suitable for process optimization and pilot-scale production under controlled GMP-like conditions.

Basic Information

Product Name	5-(1,3-Dioxolan-2-Yl)Thiophene-2-Sulfonyl Chloride
CAS No.	871825-61-5
Molecular Formula	C7H7ClO4S2
Molecular Weight	254.71 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 5-(1,3-dioxolan-2-yl)-; 5-(1,3-Dioxolan-2-yl)thiophene-2-sulfonyl chloride; 5-(2,2-Dimethyl-1,3-dioxolan-4-yl)thiophene-2-sulfonyl chloride (common mis-assignment); Thiophene-2-sulfonyl chloride, 5-(1,3-dioxolan-2-yl)-; 871825-61-5; 5-(1,3-Dioxolan-2-yl)-2-thiophenesulfonyl chloride; 5-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-thiophene-2-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxolan-2-Yl)Thiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, assay, and impurity profiles. Our quality commitment supports compliance with ISO standards and meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.