Description

Mglur5 Inhibitor CAS NO 871362-31-1 is a potent and selective small molecule antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5). This compound is a critical research tool for investigating glutamatergic signaling pathways in the central nervous system. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) for preclinical studies in neurological and psychiatric disorders.

Application

• Neuroscience Research: Fundamental studies on mGluR5 receptor function, signal transduction, and its role in synaptic plasticity.
• Drug Discovery & Development: Used as a reference standard or pharmacological tool in high-throughput screening (HTS) and lead optimization programs targeting mGluR5.
• Preclinical Disease Modeling: Investigation of therapeutic potential in conditions such as Fragile X syndrome, Parkinson's disease, anxiety, depression, and chronic pain.
• Biochemical Assays: Functional characterization and binding studies (e.g., radioligand displacement assays) to evaluate novel compounds.
• Academic & Institutional Research: Supporting PhD and postdoctoral projects focused on glutamate receptor biology and neuropharmacology.

Basic Information

Product Name	Mglur5 Inhibitor
CAS No.	871362-31-1
Molecular Formula	C16H14FN3O3S
Molecular Weight	347.36 g/mol
Synonyms	MTEP; 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine-5-carbonitrile; 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine-5-carbonitrile; mGluR5 antagonist MTEP; 5-Cyano-3-[(2-methyl-4-thiazolyl)ethynyl]pyridine; 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine-5-carbonitrile
EINECS	Contact for details

Quality Control

Our Mglur5 Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and quality specifications is provided with every shipment to ensure reproducibility and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.