Description

Evocalcet is a potent and selective calcimimetic agent, functioning as a calcium-sensing receptor (CaSR) agonist. This compound is of significant commercial and therapeutic interest for its role in regulating parathyroid hormone (PTH) secretion. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in developing treatments for mineral and bone disorders, particularly secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease on dialysis. Evocalcet CAS NO 870964-67-3 represents a key advanced pharmaceutical intermediate for the synthesis of next-generation therapeutic agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a critical intermediate in the commercial manufacturing of finished dosage forms.
• Pharmaceutical Research & Development: Serves as a reference standard and building block in preclinical and clinical studies for novel calcimimetics.
• Treatment of Secondary Hyperparathyroidism (SHPT): Key component in formulations aimed at controlling elevated parathyroid hormone levels in patients with chronic kidney disease.
• Metabolic Bone Disorder Research: Used in biochemical assays and studies investigating calcium homeostasis and bone metabolism pathways.
• Process Development & Scale-Up: Employed by chemical development teams to optimize synthetic routes and purification processes for GMP production.

Basic Information

Item	Details
Product Name	Evocalcet
CAS No.	870964-67-3
Molecular Formula	C₂₂H₂₂F₃N₃O₂
Molecular Weight	417.42 g/mol
Synonyms	Evocalcet; (R)-N-((1H-Pyrazol-1-yl)methyl)-1-(1-naphthyl)-2,2,2-trifluoroethanamine; (R)-N-((1H-Pyrazol-1-yl)methyl)-1-(naphthalen-1-yl)-2,2,2-trifluoroethanamine; KHK-7580; AMG 416 (discontinued codename); Calcimimetic KHK7580; (R)-1-(1-Naphthyl)-2,2,2-trifluoro-N-((1H-pyrazol-1-yl)methyl)ethanamine
EINECS	Contact for details

Quality Control

Our Evocalcet is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.