Description

Nitromifene CAS NO 10448-84-7 is a non-steroidal selective estrogen receptor modulator (SERM) of the triphenylethylene class, known for its potent anti-estrogenic properties. This compound is critical for research and development in endocrinology, providing a valuable tool for studying estrogen receptor signaling pathways and their modulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of advanced intermediates for therapeutic applications.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel SERM-based therapies.
• Endocrinology Studies: Used in preclinical and in-vitro research to investigate estrogen receptor antagonism, breast tissue selectivity, and hormonal feedback mechanisms.
• Biochemical Assay Development: Employed as a ligand in competitive binding assays and high-throughput screening (HTS) to identify and characterize new estrogen receptor modulators.
• Advanced Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex SERM analogs and related therapeutic candidates.
• Academic & Clinical Research: Supports fundamental studies in hormone-dependent cancers, metabolic disorders, and bone density research.

Basic Information

Product Name	Nitromifene
CAS No.	10448-84-7
Molecular Formula	C26H28NO3
Molecular Weight	402.51 g/mol
Synonyms	Nitromifene; Nitromiphene; CI-628; NSC-163063; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-2-(4-nitrophenyl)ethene; α-[4-[2-(Dimethylamino)ethoxy]phenyl]-4-nitro-α-phenylstilbene; Triphenylethylene Derivative CI-628
EINECS	Contact for details

Quality Control

Our Nitromifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.